Novi Koronavirus: Zašto Koronavirus ubija starije? Priroda: Virusi ostarjelih pluća

Autoritativni podaci pokazuju da je prosječna dob smrti od COVID-19 u svijetu starija od 70 godina!

Zašto je veća vjerojatnost da će stariji ljudi umrijeti od novih infekcija koronavirusom nego mlađi ljudi? Priroda Cell Biology je 8. prosinca objavila rezultate zajedničkog tima kineskih znanstvenika kako bi nam pomogli odgovoriti na ovo pitanje.

"In layman's terms, the novel Coronavirus invasions age the lungs of older persons." Liu Guanghui, one of the paper's corresponding authors and a researcher at the Institute of Zoology, Chinese Academy of Sciences, told Science and Technology Daily that the results of the novel Coronavirus infection showed significantly accelerated aging of lung tissues.

Virus invasion, aging signs' spike '

Klinički, glavni uzrok smrti pacijenata oboljelih od COVID-19 je zatajenje disanja zbog teške ozljede pluća.

What exactly has novel Coronavirus destroyed in the lungs? To clarify the situation, a joint research team from the Institute of Zoology of the Chinese Academy of Sciences, the First Affiliated Hospital of The Army Military Medical University and the Beijing Institute of Genomics of the Chinese Academy of Sciences conducted a detailed "cell-to-cell" and even "intracellular molecular" analysis of lung tissue from autopsy samples of elderly patients with COVID-19.

Kombinirajući patologiju, proteomiku i tehnike transkriptoma jedne{0}}one stanice{1}} velike snage, tim je analizirao patološke karakteristike 28 različitih tipova stanica u četiri glavne skupine stanica, uključujući epitelne stanice pluća, endotelne stanice, stromalne stanice i imunološke stanice.

"We found that lung cells in elderly patients showed more severe 'senility'." Some cell senescence markers, senescence related inflammatory factors and DNA oxidative damage markers were significantly upregulated, Liu said.

What are the outward manifestations of "aged" lung cells?

"We see apoptosis, shedding of lung epithelial cells." For example, liu said, there is also a reduction in cell-surface active substances, which normally support the normal dilation and contraction of the alveoli, and some basic respiratory functions of the alveoli are reduced.

Drooping, retardation, apoptosis, shedding... The performance of "old lung" was unusually prominent after the novel Coronavirus invasion.

Ciklus udara, dodajući uvredu ozljedi

"The lung tissue of the elderly may be hit in a circular fashion by the virus." Liu Guanghui told Science and Technology Daily that there are already more Novel Coronavirus receptors (ACE2) on the lung cells of the elderly than the young, and the aging of the cells is more obvious after the virus invasions. In turn, cell aging further induces the upregulation of novel Coronavirus receptors, making the cells more vulnerable to virus attack. The age-mediated "gate opening" cycle repeats, introducing more viruses and accelerating lung failure.

Osim toga, tim je na temelju bioinformatičke analize otkrio veliku akumulaciju alveolarnih epitelnih prijelaznih stanica u uzorcima plućnog tkiva COVID-19. U alveolama, alveolarne epitelne stanice tipa I odgovorne su za izmjenu plinova, ali nemaju regenerativnu sposobnost i trebaju se nadopuniti diferencijacijom alveolarnih epitelnih stanica tipa II nakon ozljede. Obilje takvih prijelaznih stanica sugerira da je podrška tipa ii blokirana.

The virus's entry into lung tissue also accelerated fibrosis, a form of lung aging, the study found. In combination with the human lung fibroblast model, we found that the silencing of longevity gene FOXO3 may promote the transformation of lung fibroblasts into myofibroblasts and mediate the occurrence of pulmonary fibrosis.

Tri strategije širokog otvaranja vrata, odsjecanja potpore, povećanja stanične fibroze i ulaska virusa u stanice pluća starijih osoba pogoršale su štetu.